崔倩倩 邱建峰 钱秀清 张昆亚 张璐 张禹 祁昕征 魏超 刘志成

中文摘要:
      目的 在体测量兔眼不同眼压水平以及急性高眼压形成后不同时刻的视神经纤维层厚度，获取急性高眼压作用所致的兔眼视神经纤维层厚度改变规律。方法 向兔眼前房注射生理盐水使眼压不断升高，形成4组急性高眼压动物模型。利用相干断层扫描仪，采用以视神经乳头为中心、直径为6 mm的辐射状扫描模式，分别扫描并测量不同眼压状态的兔眼视神经纤维层厚度。 结果 4组模型的急性高眼压为(4.50±0.35)、(6.07±0.31)、(7.74±0.26)、(10.71±0.07) kPa，视神经纤维层厚度绝对改变量分别为(-27.16±14.24)、(-33.33±6.74)、(-48.75±5.24)、(-67.29±3.89) μm，而且视神经纤维层厚度的相对改变量与眼压成线性关系，高眼压后2天兔眼眼压可以恢复正常，视神经纤维层厚度2周时基本恢复，急性高眼压低于6.65 kPa时视神经纤维层厚度更易于恢复。 结论 急性高眼压导致视神经纤维层变薄，且随眼压的升高视神经纤维层厚度变薄加重；一定时间后视神经纤维层厚度能恢复正常。
英文摘要:
      Objective To measure the rabbit retinal nerve fiber layer(RNFL) thickness in vivo under different intraocular pressures (IOP) and at different time intervals after acute high IOP, and to obtain the regularity on change of RNFL thickness with acute high IOP. Methods Four groups of acute high IOP model were formed by perfusing the saline water into the anterior chamber of rabbit eyes, then RNFL thickness under different IOPs was measured by optical coherence tomography with radial scanning mode whose center was optical papilla and diameter was 6 mm. Results The absolute change values of RNFL thickness were(-27.16±14.24), (-33.33±6.74), (-48.75±5.24), (-67.29±3.89) μm under different IOPs of (4.50±0.35), (6.07±0.31), (7.74±0.26), (10.71±0.07) kPa, respectively. The linear relationship was found between the relative change of RNFL thickness and IOP. IOP could return to the normal level within two days after acute high IOP, while the RNFL thickness could be restored at the second week, and it was easier to restore if the IOP was lower than 6.65 kPa. Conclusions The acute high IOP could cause RNFL thickness to decrease significantly with the increased acute high IOP, but it will be restored after some time.